fig2

Figure 2. Ten Success Factors of Sustainable Drug Repurposing Models. The graphic represents ten key success factors to be considered by drug developers embarking on a drug repurposing project. These factors are not presented in a sequential order and form a framework of actions. The identification of unmet patient needs and patient partnerships are key components of sustainability. The collection of evidence concerning disease prevalence, patient numbers, drug pharmacology and disease etiology, drug industrial property status, off-label or compounding use, data from past clinical studies or real world evidence and the need for extended non-clinical and clinical studies is essential in designing a sustainable repurposing project and an accurate business plan. The development of a collaborative funding framework and early discussion with regulators, HTA agencies and payers are also essential factors to implement early on in the development of a sustainable project.